Infection Prevention and Patient Safety (IPPS) training was provided at Walda Primary Hospital on January 10-15, 2021 and Mekit Primary hospital on May 4-9, 2021. The training was given to midwives, nurses, and catchment health center workers, a total of 60 participants had attended two-session training. In developing countries like Ethiopia, healthcare-associated infections are recognized as a major burden for patients, society, and healthcare management. The potential for the transmission of infections in the health care setting is high. Statistics show that a hospital is one of the most hazardous places to work. Both those receiving and providing care in the hospital are at risk of acquiring and transmitting infections through exposure to blood, body fluids, or contaminated materials. Healthcare workers may be exposed to the infection through the provision of care, invasive clinical procedures, the use of instruments and sharps expose healthcare workers to needle stick injuries and in turn to potentially infectious agents which can cause nosocomial infection or Healthcare Acquired Infection.